Born in Birmingham to parents of Polish descent, she is the middle of five children. Luisa lived in Farnborough, Hampshire where she went to St Patricks Catholic School and then onto a Catholic secondary school in Farnham called All Hallows. In 2005, she graduated from Salford University with a first class BA Hons in Performing Arts. In 2011 Luisa attended training at Second City in Chicago where she specialised in Clowning, Improvisation and Sketch Writing.
Omielan first started stand up comedy in 2008 performing at the Brighton Fringe Festival. In 2012, Omielan performed her debut stand up solo show, What Would Beyoncé Do?! as part of the Brighton Fringe later followed by the free fringe at the Edinburgh Festival. What Would Beyoncé Do?! has since had ten sell out runs at London's Soho Theatre. Omielan was later nominated at Melbourne Comedy festival for best Comedy show. The show went on to tour 12 countries and recorded as a BBC special. It was named “one of the biggest stand up hits of the decade’ by the Guardian
In 2014, Omielan was invited to perform for ten nights as part of the Montreal Just for Laughs Festival. The show then continued to have a week run in the London West End at the Leicester Square Theatre. Omielan is known for her empowering 'party' atmosphere genre of comedy. Her follow-up show Am I Right Ladies?! has had a UK tour, received critical acclaim and five star reviews. In July 2015, Omielan used crowd funding website Indiegogo to self fund a DVD recording of Am I Right Ladies?! at the Bloomsbury Theatre, which she later uploaded to her YouTube channel, in February 2018.
On 20 November 2014, she appeared on the 99th episode of The Comedian's Comedian Podcast with Stuart Goldsmith.
Autumn 2018 she adapted her live Edinburgh Fringe stage show, Politics for Bitches, into six 30 minute episodes for the BBC. Via a part documentary, part stand-up gig format, Omielan, explores a few of the socioeconomic and political issues facing young adults in the UK today.
'ABOUT AS FUNNY AS ANY COMEDY SHOW NEEDS TO GET' The Telegraph